http://www.signaling-gateway.org/update/updates/200705/nrm2168.html
Gain-of-function mutations in the tumor suppressor p53 promote oncogenesis by interfering with DNA repair.
[[...The authors argue that "a novel gain-of-function of common p53 cancer mutants in disrupting critical DNA DSB damage responses will have significant implications on the therapeutic interventions for human cancers that express p53 cancer mutants."...]]
